| Server/Service | Port | Protocol | Direction |
| ADFS (Internal) | 443 | TCP | Inbound/Outbound |
| ADFS (Proxy DMZ) or WAP Server | 443 | TCP | Inbound/Outbound |
| Microsoft Online Portal (Website) | 443 | TCP | Inbound/Outbound |
| Outlook Web Access (Website) | 443 | TCP | Inbound/Outbound |
| Lync/Skype for Business Client | 443 | TCP | Inbound/Outbound |
| SharePoint Online (Website) | 443 | TCP | Inbound/Outbound |
| Outlook for Mac | 443 | TCP | Inbound/Outbound |
| Outlook Client | 443 | TCP | Inbound/Outbound |
| Mail Routing | 25 | TCP | Inbound/Outbound |
| SMTP Relay (requires TLS) | 587 | TCP | Inbound/Outbound |
| Simple IMAP4 migration Tool | 143/993 | TCP | Inbound/Outbound |
| POP3 (requires SSL) | 995 | TCP | Inbound/Outbound |
| DirSync/Azure Active Directory Sync | 80/443 | TCP | Inbound/Outbound |
| Exchange Migration Tool | 80/443 | TCP | Inbound/Outbound |
| IMAP Migration Tool | 80/443 | TCP | Inbound/Outbound |
| Exchange Management Console | 80/443 | TCP | Inbound/Outbound |
| Exchange Management Shell | 80/443 | TCP | Inbound/Outbound |
| Lync (Data Sharing Sessions) | 443 | TCP | Outbound |
| Lync (Video, Audio, Application Sharing) | 443 | TCP | Outbound |
| Lync (Audio & Video) | 3478 | UDP | Outbound |
| Lync (Audio & Video) | 50000-59999 | TCP/UDP | Outbound |
| Lync Mobile Push iOS Only | 5223 | TCP | Outbound |
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